Advance in molecular targeted therapy for primary hepatocellular carcinoma

Molecular Targeted Therapy for Growth Factors in Hepatocellular Carcinoma

Treatments for HCC are classified into local and systemic therapies. Various local treatment modalities, such as resection, local ablation, transcatheter arterial chemoembolization (TACE), and liver transplantation, are available at present. The most suitable treatment modality for HCC is selected according to the tumor stage, grade of liver dysfunction, and performance status of the patient [1...

Molecular Targeted Therapy for Hepatocellular Carcinoma: Where Are We Now?

Signaling Pathway and Molecular-Targeted Therapy for Hepatocellular Carcinoma

In recent years, molecular-targeted agents have been used clinically to treat various malignant tumors. In May 2009, sorafenib (Nexavar ) was approved in Japan for ‘unresectable hepatocellular carcinoma (HCC)’, and was the first molecular-targeted agent for use in HCC. To date, sorafenib is the only molecular-targeted agent whose survival benefit has been demonstrated in two global phase III ra...

Signaling Pathway and Molecular-Targeted Therapy for Hepatocellular Carcinoma

In recent years, molecular-targeted agents have been used clinically to treat various malignant tumors. In May 2009, sorafenib (Nexavar ) was approved in Japan for ‘unresectable hepatocellular carcinoma (HCC)’, and was the first molecular-targeted agent for use in HCC. To date, sorafenib is the only molecular-targeted agent whose survival benefit has been demonstrated in two global phase III ra...

Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.

In recent years, molecular-targeted agents have been used clinically to treat various malignant tumors. In May 2009, sorafenib (Nexavar®) was approved in Japan for 'unresectable hepatocellular carcinoma (HCC)', and was the first molecular-targeted agent for use in HCC. To date, sorafenib is the only molecular-targeted agent whose survival benefit has been demonstrated in two global phase III ra...